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Updated: Dec 6, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
Published on: March 31, 2022
Importance of DNA Repair: Recent Advances
Yarosh Daniel B1, Tewari Angela1
1Daniel B. Yarosh, Inc., Merrick, NY (D.B.Y.), Department of Dermatology, Kings College Hospital, NHS Foundation Trust, London SEI 9RT, United Kingdom (A.T.).
Abstract:
Our defense against solar ultraviolet (UV) damage to skin comprises endogenous mechanisms of DNA repair and pigmentation, and exogenous application of light-absorbing and reflecting sunscreens. Our most important endogenous defense, DNA repair, has been the focus of molecular and clinical research, and recent advances are summarized here. The approach of using microbial DNA repair enzymes to augment the natural DNA repair capacity of skin has gained acceptance in many commercial products, and clinical studies have supported their benefits.
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