Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmental predictors of suicide attempts from childhood to early adulthood: a 15-year prospective cohort study.

Lancet regional health. Americas·2026
Same author

Clinical and sociodemographic correlates of body mass index in a large multicenter obsessive-compulsive disorder sample.

Eating and weight disorders : EWD·2026
Same author

Psychometric Properties and Longitudinal Predictors of the Columbia Suicide Severity Rating Scale (C-SSRS) in a Brazilian Community Cohort: A 15-Year Follow-Up Study.

Suicide & life-threatening behavior·2026
Same author

Prenatal stress, intimate partner violence and maternal cortisol trajectories: insights from a prospective birth cohort from São Paulo, Brazil.

Scientific reports·2026
Same author

Prurigo nodularis: case series of 28 Brazilian patients treated with psychotropic medications.

Anais brasileiros de dermatologia·2026
Same author

Latent Heterogeneity in Depressive Symptoms, Suicidal Thoughts and Behaviors Among Brazilian Medical Students: Prevalence, Associated Factors, and Group Differences.

Trends in psychiatry and psychotherapy·2026

Related Experiment Video

Updated: Dec 6, 2025

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

4.0K

Delayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy.

Stephanie Toscano Kasabkojian1, Alexandre Jack Dwan1, Maria Paula Maziero2

  • 1Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.

World Neurosurgery
|October 6, 2020
PubMed
Summary

Gamma Knife ventral anterior capsulotomy effectively treats obsessive-compulsive disorder. However, rare, delayed complications like brain edema and cysts can occur, highlighting the need for vigilant follow-up after radiosurgery.

Keywords:
Brain edemaCase reportCystsObsessive-compulsive disorderRadiosurgery

More Related Videos

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

8.3K
A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
12:09

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

Published on: June 16, 2013

11.8K

Related Experiment Videos

Last Updated: Dec 6, 2025

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

4.0K
Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

8.3K
A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
12:09

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

Published on: June 16, 2013

11.8K

Area of Science:

  • Neurosurgery
  • Radiosurgery
  • Psychiatry

Background:

  • Gamma Knife ventral anterior capsulotomy is a recognized treatment for refractory obsessive-compulsive disorder (OCD).
  • While generally well-tolerated, radiosurgery can lead to delayed complications, even years post-treatment.
  • This case details unusual complications arising from high-dose radiation therapy.

Observation:

  • A 55-year-old male with treatment-resistant OCD underwent Gamma Knife ventral anterior capsulotomy (180 Gy).
  • Initial symptom improvement was followed by a manic episode, cognitive decline, visual hallucinations, confabulation, and frontal lobe dysfunction.
  • Postoperative imaging at 20 months revealed left hemisphere brain edema and a right hemisphere cyst.

Findings:

  • The patient experienced significant neurological and psychiatric sequelae attributed to the radiosurgical procedure.
  • High radiation doses may affect unintended neural pathways, leading to delayed adverse effects.
  • Brain edema and cyst formation were observed long after the initial treatment.

Implications:

  • This case underscores the potential for delayed, abnormal complications following Gamma Knife ventral anterior capsulotomy.
  • It emphasizes the critical need for meticulous clinical assessment and neuroimaging surveillance post-procedure.
  • Careful consideration of radiation dosage and target localization is crucial to minimize risks.