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Updated: Dec 6, 2025
12:04
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
Published on: December 9, 2022
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Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae
Joseph L Roberts1, Guanglu Liu2, Trevor M Darby3
1Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA, USA; Nutrition and Health Sciences Program, Emory University, Atlanta, GA, USA.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|October 6, 2020
Summary
Probiotic supplementation with Bifidobacterium adolescentis improved bone fracture healing by reducing gut permeability and systemic inflammation. This beneficial bacteria enhances intestinal barrier function and protects the skeleton post-fracture.
Area of Science:
- Microbiology
- Orthopedics
- Immunology
Background:
- The gut microbiota significantly impacts host health and disease.
- Previous research highlighted the gut microbiota's and probiotics' benefits for bone health.
- The role of probiotics in skeletal injury recovery and associated systemic effects is largely unknown.
Purpose of the Study:
- To investigate the potential of probiotics in modulating bone repair after fracture.
- To determine if probiotics can mitigate fracture-induced systemic inflammation.
Main Methods:
- Induction of femur fracture in a study model.
- Assessment of gut permeability changes post-fracture.
- Dietary supplementation with Bifidobacterium adolescentis.
- Evaluation of systemic inflammatory markers.
- Analysis of fracture callus and intact skeleton status.
Main Results:
- Femur fracture increased gut permeability for up to 7 days.
- Bifidobacterium adolescentis supplementation reduced gut permeability.
- Probiotics significantly dampened the systemic inflammatory response to fracture.
- Accelerated fracture callus cartilage remodeling and enhanced protection of the intact skeleton were observed.
Conclusions:
- Dietary probiotics, specifically Bifidobacterium adolescentis, can enhance bone fracture healing.
- Probiotic intervention normalizes gut barrier function and reduces systemic inflammation following skeletal trauma.
- Targeting the gut microbiota with beneficial bacteria offers a therapeutic strategy against systemic pathologies associated with bone fractures.
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