Band power modulation through intracranial EEG stimulation and its cross-session consistency

Area of Science:

• Neuroscience
• Neurology
• Biomedical Engineering

Background:

• Intracranial electrical stimulation is used for epilepsy evaluation and neuromodulation.
• Consistent neural responses are crucial for effective therapeutic neuromodulation.
• The cross-session consistency of brain stimulation effects is currently unknown.

Purpose of the Study:

• To investigate the within-subject, cross-session consistency of electrophysiological responses to intracranial electrical stimulation (iEEG).

Main Methods:

• Analyzed iEEG data from 79 epilepsy patients undergoing brain stimulation during a memory experiment.
• Quantified stimulation effects by measuring band power modulation.
• Compared stimulation effects across sessions and against baseline periods.

Main Results:

• In most sessions, stimulation effects were indistinguishable from baseline fluctuations.
• Stimulation effects demonstrated consistency in only one-third of session pairs.
• Cross-session consistency correlated with increased band power and similar baseline conditions.

Conclusions:

• Direct electrical brain stimulation exhibits variable efficacy across sessions.
• Findings inform the design of more effective neuromodulation strategies.
• Understanding session variability is key for therapeutic applications.