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Related Experiment Video

Updated: Dec 6, 2025

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

Do human embryos have the ability of self-correction?

Raoul Orvieto^1,2,3, Chen Shimon⁴, Shlomit Rienstein^5,6

¹Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), 56261, Ramat Gan, Israel. Raoul.orvieto@sheba.health.gov.il.

Reproductive Biology and Endocrinology : RB&E

|October 7, 2020

Summary

Human embryos can expel abnormal cells, a self-correction mechanism. This finding challenges current preimplantation genetic testing accuracy for aneuploidy, potentially leading to discarding viable embryos.

Keywords:

Blastocyst Human embryo Mosaicism PGT Self-correction

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Area of Science:

Reproductive Biology
Genetics
Developmental Biology

Background:

Human embryogenesis is prone to cell division errors, resulting in aneuploidy and mosaicism.
Embryo self-correction mechanisms have been observed in mice but lack human data.

Purpose of the Study:

To investigate the self-correction capabilities of human embryos.
To determine if human embryos can eliminate abnormal blastomeres.

Main Methods:

Analyzing blastocysts and their expelled cell debris/fragments.
Utilizing whole genome amplification for genetic analysis.
Comparing genetic results between blastocysts and their corresponding debris.

Main Results:

Seven of 11 blastocyst-debris pairs showed discordant genetic results.
Aneuploid debris was observed in some euploid blastocysts.
Debris sometimes exhibited additional aneuploidies compared to the blastocyst.

Conclusions:

Human embryos possess a mechanism to expel abnormal blastomeres as debris.
This expulsion challenges the reliability of current preimplantation genetic testing for aneuploidy.
Current testing may yield false positives due to cell-free DNA from expelled debris.