A well-appearing infant with a sudden anisocoria
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Updated: Dec 6, 2025

Author Spotlight: An Automated Method for Assessing Visual Acuity in Infants and Toddlers Using an Eye-Tracking System
Published on: March 17, 2023
Alessia Giuseppina Servidio1, Francesca Peri2, Andrew Tenore3
1Clinical Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Friuli-Venezia Giulia, Italy servidioalessiag@gmail.com.
Insights
A 10-month-old boy presented with sudden unilateral mydriasis after minor head trauma. This case highlights the importance of evaluating even seemingly minor head injuries in pediatric patients presenting with neurological changes.
Area of Science:
- Pediatric Neurology
- Ophthalmology
Background:
- Sudden unilateral mydriasis in infants can be a sign of serious underlying pathology.
- A history of head trauma, even minor, warrants careful neurological assessment in children.
Purpose of the Study:
- To report a case of unilateral mydriasis in a pediatric patient following minor head trauma.
- To emphasize the diagnostic considerations and management of anisocoria in infants.
Main Methods:
- Clinical case presentation.
- Detailed neurological and ophthalmological examination.
- Review of medical history, including recent trauma.
Main Results:
- A 10-month-old boy developed left unilateral mydriasis.
- The child had a history of minor head trauma two days prior to presentation.
- Neurological and physical examinations were otherwise normal.
Conclusions:
- Unilateral mydriasis in a pediatric patient, even after minor head trauma, requires thorough investigation.
- Prompt medical evaluation is crucial to rule out significant intracranial pathology.
Abstract:
Case presentationA 10-month-old boy was admitted to the emergency department due to a sudden onset of left unilateral mydriasis (figure 1). His medical history was unremarkable. A minor head trauma 2 days before was reported, without alarming signs or symptoms. His mother was putting him to sleep, after coming back from work, when she noticed a different pupil size and promptly went to the ED with her husband. The parents denied any use of medications, including nebulised therapy or direct contact with plants. The child was well appearing and his vital signs were within the standard age limits. His extraocular motility was normal as well as the rest of his neurological and physical examination. Parents' behaviour was somehow remarkable. Even though the child was not suffering, the mother seemed very worried while the father was nervous and aggressive, repeatedly asking for a discharge.
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