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Updated: Dec 6, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
Transcriptional regulation of memory B cell differentiation
Brian J Laidlaw1, Jason G Cyster2,3
1Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. brian.laidlaw@wustl.edu.
Abstract:
Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to develop vaccines that induce broadly protective MBCs to rapidly mutating pathogens have not yet been successful. Better understanding of the signals regulating MBC development and function are essential to overcome current challenges hindering successful vaccine development. Here, we discuss recent advancements regarding the signals and transcription factors regulating germinal centre-derived MBC development and function.
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