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Considerations for future novel human-infecting coronavirus outbreaks
Georges Sinclair1,2, Philippa Johnstone3, Mustafa Aziz Hatiboglu1
1Department of Neurosurgery, Bezmialem Vakif University Medical School, Istanbul, Turkey.
Surgical Neurology International
|October 7, 2020
Summary
This study compares SARS-CoV-2, SARS-CoV, and MERS, focusing on neuroinvasion and its effects on brain tumors. It also reviews past pandemic responses to inform future outbreak management strategies.
Area of Science:
- Virology
- Neuroscience
- Epidemiology
Background:
- Compares severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV, and Middle East respiratory syndrome (MERS) pathophysiology and clinical manifestations.
- Investigates the neuroinvasive potential of beta-coronaviruses (CoVs) and their impact on patients with primary or metastatic brain tumors.
Discussion:
- Analyzes lessons learned from past large-scale health crises, including South Korea's response to MERS.
- Examines the adaptation of disaster management strategies for SARS-CoV-2 based on prior outbreak experiences.
Key Insights:
- Highlights pathophysiological and clinical similarities among beta-CoVs, particularly concerning neurological effects.
- Emphasizes the importance of understanding neuroinvasion for managing CoV outbreaks in vulnerable populations like brain tumor patients.
Outlook:
- Assesses infection prevention and control strategies for future pandemic preparedness.
- Recommends strategies to contain the spread of novel viruses based on historical data and current understanding.
Keywords:
Infection control and preventionMiddle East respiratory syndromeNeuroinvasionSevere acute respiratory syndrome coronavirusSevere acute respiratory syndrome coronavirus 2More Related Videos
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