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The Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis

Han-Teo Lee1,2, Sanghyeon Oh1,2, Du Hyun Ro1,2,3

  • 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science, Seoul National University, Seoul, Korea.

Journal of Lipid and Atherosclerosis
|October 7, 2020
PubMed

Insights

Epigenetic factors like DNA methylation and histone modifications are key in atherosclerosis. This study explores how histone acetylation influences DNA methylation, impacting gene expression in this common arterial disease.

Area of Science:

  • Cardiovascular biology
  • Epigenetics
  • Molecular pathology

Background:

  • Atherosclerosis is a prevalent coronary artery disease characterized by vascular inflammation and plaque buildup.
  • Epigenetic mechanisms, including DNA methylation and histone modifications, play significant roles in atherosclerosis development.
  • These epigenetic systems are known to be interconnected and interdependent.

Purpose of the Study:

  • To investigate the functional relationship between DNA methylation and histone modification systems in atherosclerosis.
  • To highlight recent findings on how histone acetylation may guide DNA methylation.
  • To explore the role of DNA methylation in regulating gene expression during the progression of atherosclerosis.

Main Methods:

  • Literature review focusing on epigenetic mechanisms in atherosclerosis.
  • Analysis of recent studies examining the interplay between DNA methylation and histone modifications.
  • Exploration of functional linkages and regulatory pathways.

Main Results:

  • Evidence suggests histone acetylation can direct DNA methylation processes.
  • DNA methylation appears to be a critical regulator of gene expression in the context of atherosclerosis.
  • The interrelation between these epigenetic systems offers potential therapeutic targets.

Conclusions:

  • The functional linkage between histone acetylation and DNA methylation is crucial in atherosclerosis.
  • Understanding this interplay can provide insights into novel therapeutic strategies for managing coronary artery disease.
  • Epigenetic regulation is a key determinant of gene expression in vascular pathology.

Keywords:
AcetylationAtherosclerosisDNA methylationHistones

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