Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.8K
Autoimmune Disorders01:29

Autoimmune Disorders

1.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.2K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.1K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
Development of Immunocompetence01:22

Development of Immunocompetence

607
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
607
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

2.5K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness and probability of full disease control with canakinumab in familial Mediterranean fever: real-world data from the AIDA Network.

Rheumatology (Oxford, England)·2026
Same author

Patient and caregiver perspectives on transition from pediatric to adult care in inborn errors of immunity: a Polish multicenter survey.

Frontiers in immunology·2026
Same author

Long-term remission and monocyclic course in Still's disease patients starting canakinumab early: data from the international AIDA network registry.

Seminars in arthritis and rheumatism·2026
Same author

Immune Dysregulation After COVID-19: Longitudinal Analysis up to 9 Months.

International journal of molecular sciences·2026
Same author

Non-classical immune checkpoint CD137/CD137L and CD200/CD200R expressions are regulated by the tumor immune microenvironment in lymph node aspirates from lung cancer patients.

Frontiers in immunology·2026
Same author

Long-term anakinra therapy in Schnitzler syndrome: real-world evidence on remission of neutrophilic dermatitis and systemic inflammation, safety, biomarker insights and dose optimization.

Frontiers in immunology·2026

Related Experiment Video

Updated: Dec 6, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.6K

From infections to autoimmunity: Diagnostic challenges in common variable immunodeficiency.

Ewa Więsik-Szewczyk1, Karina Jahnz-Różyk2

  • 1Department of Internal Medicine, Pulmonology, Allergy and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, Warsaw 04-141, Poland. ewa.w.szewczyk@gmail.com.

World Journal of Clinical Cases
|October 7, 2020
PubMed
Summary

Common variable immunodeficiency (CVID) is a primary antibody deficiency often missed due to non-specific symptoms. Early diagnosis and tailored treatment are crucial for managing infections, autoimmunity, and increased cancer risk in CVID patients.

Keywords:
AdultsComplicationsEarly diagnosisImmunoglobulin replacementPrimary antibody deficiencyRecurrent respiratory tract infections

More Related Videos

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.4K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.8K

Related Experiment Videos

Last Updated: Dec 6, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.6K
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.4K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.8K

Area of Science:

  • Immunology
  • Clinical Medicine
  • Oncology

Background:

  • Common variable immunodeficiency (CVID) is the most frequent clinically significant primary antibody deficiency in adults.
  • Early CVID symptoms, like recurrent respiratory infections, are often non-specific, leading to diagnostic delays in primary care.
  • CVID diagnosis is frequently complicated by coexisting autoimmunity, inflammation, or lymphoproliferation, diverting attention from the underlying immune deficiency.

Purpose of the Study:

  • To enhance healthcare professional awareness of CVID.
  • To present diagnostic features that can shorten the delay in CVID management.
  • To review clinical symptoms, complications, and laboratory findings associated with CVID.

Main Methods:

  • Review of clinical symptoms, complications, and laboratory abnormalities in CVID patients.
  • Discussion of current and emerging immunoglobulin replacement therapy (IRT) administration routes.
  • Emphasis on diagnostic challenges and the need for increased clinical suspicion.

Main Results:

  • CVID patients face increased susceptibility to infections and a higher incidence of malignancies, particularly lymphomas and gastric carcinoma.
  • Immunoglobulin replacement therapy is the primary treatment, with newer subcutaneous methods improving patient adherence.
  • Diagnostic delay remains a significant global issue for CVID patients.

Conclusions:

  • Timely diagnosis and precise patient stratification are essential for effective CVID management.
  • Earlier diagnosis and monitoring may help mitigate CVID complications, including malignancy risk.
  • Further research is needed to identify prognostic factors and develop personalized treatment protocols for CVID.