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Epidermolytic acanthoma: A case report.

Ariana S Ginsberg1, Archeta Rajagopalan1, Joseph P Terlizzi1

  • 1Department of Colon and Rectal Surgery, Laser Surgery Care, New York, NY 10011, United States.

World Journal of Clinical Cases
|October 7, 2020
PubMed
Summary

Epidermolytic acanthoma (EA) is a rare, benign skin lesion often mistaken for other conditions. Increased awareness and accurate diagnosis are crucial to prevent unnecessary patient treatment and anxiety.

Keywords:
Anal cancerCase reportCondyloma accuminatumEpidermolytic acanthomaEpidermolytic hyperkeratosisVerruca

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Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Epidermolytic acanthoma (EA) is a rare, benign skin neoplasm.
  • Characterized by epidermolytic hyperkeratosis on histology.
  • Typically presents in the genital area.

Observation:

  • EA is frequently misdiagnosed as condyloma accuminatum, verruca, or seborrheic keratosis.
  • A case of EA in a human immunodeficiency virus-positive male presenting as an anal papule is detailed.
  • Differential diagnoses included molluscum contagiosum, anal condyloma, and basal cell carcinoma.

Findings:

  • Histologic examination confirmed EA.
  • Misdiagnosis can lead to incorrect patient counseling and unnecessary treatments.

Implications:

  • Highlights the importance of accurate diagnosis for benign skin lesions.
  • Emphasizes the need for increased clinician awareness of EA.
  • Pathologic evaluation is essential for definitive diagnosis and appropriate patient management.