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Updated: Dec 6, 2025
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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
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[Intraoperative OCT in retinal detachment with macular involvement]
V Degenhardt1, R Khoramnia1, J Storr2
1Klink und Poliklinik für Augenheilkunde, Universität Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.
Summary
Intraoperative optical coherence tomography (iOCT) provides real-time retinal insights during detachment surgery. It reveals subretinal fluid and outer retinal layer changes, offering data sometimes unseen by the naked eye.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Medical Imaging
Background:
- Intraoperative optical coherence tomography (iOCT) is a novel technology for visualizing retinal structures during surgery.
- It integrates with the operating microscope to enhance surgical visualization.
Purpose of the Study:
- To analyze retinal behavior and morphological changes during surgery for retinal detachment with macular involvement.
- To evaluate the utility of iOCT in visualizing these changes.
Main Methods:
- Retrospective analysis of 41 eyes with macula-off retinal detachment.
- Pars plana vitrectomy (PPV) performed with iOCT guidance.
- Qualitative analysis of intraoperative retinal morphology at key surgical moments.
Main Results:
- iOCT successfully visualized macular detachment in 63% of cases; others exceeded scan depth.
- Subretinal fluid detected in 53.7% of eyes; outer retinal layers showed wave-like configuration in 22%.
- Persistent subretinal fluid found in 61% of eyes post-tamponade, often undetectable by naked eye.
Conclusions:
- iOCT rarely alters surgical plans but provides crucial real-time fluid and structural data.
- The clinical significance of persistent subretinal fluid and outer retinal folds post-surgery requires further investigation.
- These findings may serve as potential prognostic indicators for surgical outcomes.
