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Updated: Dec 6, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Navigating Ethical Practices in the Era of High Cost Hematology
Natalie Ertz-Archambault1, Nandita Khera2
1Division of Hematology and Medical Oncology, Mayo Clinic, 5777 East Mayo Blvd., Phoenix, AZ, 85054, USA. Natalie.Ertz@gmail.com.
Purpose Of Review:
In this review article, we will highlight ethical issues faced by hematologists due to a growing constellation of expensive diagnostics and therapeutics in hematology. We outline the important issues surrounding this topic including stakeholders, cost considerations, and various ethical challenges surrounding access to care, communication about costs, and individual vs. societal responsibilities. We review available tools to navigate these ethical themes and offer potential solutions.
Recent Findings:
We identified several gaps in the literature on the topic of ethical issues in hematology treatment and supplement by non-hematological cancer and general medical literature. We propose proactive solutions to address these problems to include cost transparency, utilization of evidence-based decision making tools, application of the four quadrant approach to ethical care, and advanced systems-based practice curriculum for physician trainees.
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