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Requirements for Animal Experiments: Problems and Challenges
Flavia Fontana1, Patrícia Figueiredo1, João P Martins1
1Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
Small (Weinheim an Der Bergstrasse, Germany)
|October 7, 2020
Summary
In vivo models are crucial for drug discovery but present ethical and economic challenges. This review explores alternatives to animal testing that could advance research with further development and investment.
Area of Science:
- Pharmacology and Toxicology
- Biomedical Research Ethics
Background:
- In vivo models are essential for preclinical drug screening.
- Animal testing in drug discovery faces significant ethical and economic considerations.
Purpose of the Study:
- To discuss the challenges and impacts of animal experiments in drug discovery.
- To review potential alternatives to in vivo models.
Main Methods:
- Literature review and critical analysis of current practices.
- Exploration of emerging alternative methodologies.
Main Results:
- In vivo models present limitations in translatability and raise ethical concerns.
- Several alternative approaches show promise for replacing animal studies.
Conclusions:
- Further development, optimization, and investment are necessary for alternative models.
- Transitioning away from animal testing requires a multi-faceted approach.
