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Case Report: Sweet Syndrome in Patients with Sporotrichosis: A 10-Case Series

Ísis Maria Firmino de Lima1, Cláudia Elise Ferraz2,3, Reginaldo Gonçalves de Lima-Neto2,3

  • 11Federal University of Pernambuco, Recife, Brazil.

The American Journal of Tropical Medicine and Hygiene
|October 7, 2020
PubMed

Insights

Human sporotrichosis, a fungal infection, is increasing, particularly from cats in Brazil. This study highlights an uncommon association between Sporothrix brasiliensis infection and Sweet syndrome, a severe skin reaction.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Human sporotrichosis is an emerging globally distributed fungal infection.
  • Zoonotic transmission via felines has notably increased in Brazil.
  • Sporothrix brasiliensis exhibits higher virulence and atypical presentations.

Purpose of the Study:

  • To report cases of sporotrichosis caused by Sporothrix brasiliensis.
  • To highlight the uncommon association with Sweet syndrome.
  • To alert healthcare professionals in endemic areas.

Main Methods:

  • Case series of 10 patients.
  • Clinical and etiological investigation of sporotrichosis cases.
  • Identification of Sporothrix brasiliensis as the causative agent.

Main Results:

  • All 10 patients were infected with Sporothrix brasiliensis.
  • All patients developed Sweet syndrome, an uncommon hypersensitivity reaction.
  • Sporothrix brasiliensis was linked to feline transmission and severe disease.

Conclusions:

  • Sporothrix brasiliensis infection can lead to Sweet syndrome.
  • This association is critical for diagnosis and management in endemic regions.
  • Increased vigilance for atypical sporotrichosis presentations is necessary.

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