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Updated: Dec 6, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
One year in review 2020: pathogenesis of primary Sjögren's syndrome
Michele Bombardieri1, Ourania D Argyropoulou2, Francesco Ferro3
1Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, UK.
Abstract:
The pathogenesis of primary Sjögren's syndrome (pSS) remains poorly understood. However, important efforts have been made during the last few months. In this review, following the others of this series we will summarise the most recent literature on pSS pathogenesis focusing in particular on new insights into pSS animal models, genetics and epigenetics, innate and adaptive immune system abnormalities and tertiary lymphoid structures. Hopefully, novel insights into pSS pathogenesis will pave the way to new therapeutic approaches to the disease improving patients' management and prognosis.
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