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Related Experiment Video

Updated: Dec 6, 2025

Focal Laser Ablation of Prostate Cancer: An Office Procedure
11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

8.2K

[Laser in prostate cancer. Applicability.]

Alvaro Yebes1, Juan Gómez Rivas2, Carlos Toribio1

  • 1Servicio de Urología. Hospital Universitario La Paz. Madrid. España. Universidad Autónoma de Madrid. Madrid. España.

Archivos Espanoles De Urologia
|October 7, 2020
PubMed
Summary
This summary is machine-generated.

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Focal laser therapies, including photodynamic therapy with TOOKAD, show promise for localized prostate cancer, offering gland preservation and minimal side effects compared to radical treatments. Further research is needed, but these techniques may represent a future approach.

Area of Science:

  • Oncology
  • Urology
  • Medical Technology

Background:

  • Increasing incidence of low-risk, localized prostate cancer necessitates novel treatment strategies.
  • Focal therapies aim to preserve the prostate gland, avoiding overtreatment in selected patients.
  • Laser-based focal ablation and photodynamic therapy offer potential alternatives with fewer adverse events than radical treatments.

Purpose of the Study:

  • To review the literature on laser focal therapies for localized prostate cancer.
  • To evaluate the efficacy and safety of focal laser ablation and photodynamic therapy.
  • To assess the potential future role of these techniques in prostate cancer management.

Main Methods:

  • Extensive literature review of studies on focal laser treatments for localized prostate cancer.
Keywords:
Ablación focalCáncer de próstata de bajo riesgoCáncer de próstata localizadoFocal ablationFocal therapyLaserLocalized prostate cancerLow-risk prostate cancerLáserPhotodynamic therapyTOOKADTerapia focalTerapia fotodinámica

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  • Searches conducted in PubMed and Embase using relevant keywords.
  • Analysis of clinical trial data and reported outcomes for photodynamic therapy with TOOKAD and focal laser ablation.

    • Main Results:

    • Photodynamic therapy with TOOKAD is the only focal therapy evaluated in a Phase III trial, demonstrating reduced progression rates compared to active surveillance.
    • Studies show up to 80% negative biopsies six months post-TOOKAD treatment.
    • Focal laser ablation and photodynamic therapy minimally impact quality of life, with mild, transient side effects like dysuria and hematuria.

    Conclusions:

    • Focal laser therapies show promise for localized prostate cancer, with minimal adverse events and gland preservation.
    • Photodynamic therapy with TOOKAD has demonstrated positive outcomes in clinical trials.
    • While not yet standard practice outside clinical trials, laser focal therapies represent a potential future direction for localized prostate cancer management.