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Updated: Dec 6, 2025

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions
Eloah Latocheski1, Gean M Dal Forno, Thuany M Ferreira
1LaCBio - Laboratory of Biomimetic Catalysis, Department of Chemistry, Federal University of Santa Catarina - UFSC, Campus Trindade, 88040-900 Florianópolis, SC, Brazil. josiel.domingos@ufsc.br.
Abstract:
Cleavage of C-O and C-N bonds mediated by transition metals is a promising bioorthogonal approach to rescue the activity of caged molecules, such as proteins and cytotoxic drugs, under biological conditions. However, the precise mechanism of such uncaging reactions remains elusive. This review provides mechanistic insights into metal-mediated bond-cleavage reactions, with the goals of understanding the main factors that influence the reaction and aiding the rational development of new caging groups/catalysts for chemical biology and drug-delivery applications.
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