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Related Experiment Video

Updated: Dec 6, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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CD9 expression in vascular aging and atherosclerosis.

Jae-Ryong Kim1, Joon Hyuk Choi2

  • 1Department of Biochemistry and Molecular Biology, Smart-aging Convergence Research Center, Yeungnam University College of Medicine, Daegu, Korea.

Histology and Histopathology
|October 7, 2020
PubMed
Summary

CD9 protein expression increases with vascular aging and is highly prevalent in atherosclerosis. This suggests CD9 plays a role in artery aging and the development of atherosclerosis.

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Area of Science:

  • Vascular Biology
  • Immunohistochemistry
  • Atherosclerosis Research

Background:

  • CD9, a tetraspanin protein, is involved in cellular processes like signaling and migration.
  • Previous studies linked CD9 to tumor progression, but its role in vascular aging and atherosclerosis is unclear.

Purpose of the Study:

  • To investigate the immunohistochemical expression of CD9 in normal aging arteries and atherosclerotic arteries.
  • To determine the association between CD9 expression and vascular senescence and atherosclerosis pathogenesis.

Main Methods:

  • Immunohistochemical staining was performed on tissue microarrays.
  • Samples included normal young arteries (0-60 years), normal old arteries (61-80 years), and atherosclerotic arteries.
  • CD9 expression levels were quantified and compared across groups.

Main Results:

  • CD9 expression was low in normal young arteries (10.8%) but significantly higher in normal old arteries (30.0%, P<0.01).
  • CD9 expression was markedly elevated in atherosclerotic arteries (97.0%), found in smooth muscle cells, endothelial cells, macrophages, and plaques.
  • Atherosclerotic arteries showed significantly higher CD9 expression than both young and old normal arteries (P<0.01).

Conclusions:

  • CD9 expression increases with vascular aging.
  • CD9 is significantly upregulated in atherosclerosis, indicating a potential role in its pathogenesis.
  • CD9 may be an important factor in vascular senescence and the development of atherosclerotic disease.