Related Experiment Video

Updated: Dec 6, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.6K

The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A

Liman Luo1,2,3, Menglu Fu1,3, Yuanyuan Li1,3

  • 1Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Clinical Cardiology
|October 7, 2020
PubMed

Insights

Comorbidities and cardiac injury significantly worsen prognosis for COVID-19 patients. Monitoring organ injury indicators and managing comorbidities are crucial for improving outcomes in coronavirus disease 2019 patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Investigated the link between pre-existing conditions and cardiac issues in COVID-19 patients.
  • Assessed the impact of comorbidities and cardiac injury on coronavirus disease 2019 prognosis.

Purpose of the Study:

  • To determine if underlying comorbidities and cardiac injury are associated with prognosis in COVID-19 patients.
  • To evaluate the risk of severity and mortality in coronavirus disease 2019 patients with various comorbidities and cardiac injury.

Main Methods:

  • Systematic literature search across major databases (PubMed, EMBASE, Web of Science, Cochrane Library) from December 2019 to July 2020.
  • Utilized odds ratios (OR) and 95% confidence intervals (95% CI) to quantify associations.
  • Analyzed data from 124 included studies.

Main Results:

  • COVID-19 patients with comorbidities faced a higher risk of severity and mortality.
  • Specific comorbidities like hypertension, diabetes, cardiovascular diseases, COPD, CKD, and cancer showed significantly increased risks.
  • Acute cardiac injury was more prevalent in severe cases and linked to higher in-hospital mortality.

Conclusions:

  • Both comorbidities and acute cardiac injury are strongly associated with poor prognosis in coronavirus disease 2019.
  • Continuous monitoring of organ injury markers and attention to comorbidities are essential for managing COVID-19 patients.
Abstract

Keywords:
COVID-19cardiac injurycomorbiditiesmeta-analysismortalityseverity

More Related Videos

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.6K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.1K

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.8K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
670
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Causality in Epidemiology01:21

Causality in Epidemiology

Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.3K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
718