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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jul 3, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

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Versatile composite hydrogels for drug delivery and beyond.

Yi-Hua Chiang1, Meng-Ju Wu, Wei-Chin Hsu

  • 1Faculty of Pharmacy & Center for Advanced Pharmaceutics and Drug Delivery Research & One Health Research Center, National Yang-Ming University, Taipei 112, Taiwan. tehmin@ym.edu.tw.

Journal of Materials Chemistry. B
|October 7, 2020
PubMed
Summary

This study introduces a novel protein-based hydrogel system, investigating its dual wet and dry state properties. The material shows promise for tunable drug delivery and versatile absorption applications.

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Polymer Chemistry

Background:

  • Hydrogels are widely used but rarely evaluated in both wet and dry states.
  • Protein-based hydrogels offer biocompatibility and tunable properties.
  • Current methods often require separate evaluations for wet and dry applications.

Purpose of the Study:

  • To investigate a novel bovine serum albumin (BSA)-based composite hydrogel in both wet and dry states.
  • To develop an efficient platform for studying drug delivery and release kinetics.
  • To explore the potential of these hydrogels for absorption applications.

Main Methods:

  • BSA solutions were crosslinked with organosilanes to form hydrogels.
  • Wet gels were tested for injectability and drug delivery using a one-plate microplate platform.
  • Dry gels were prepared by varying organosilane ratios and phosphate content, and their absorption capacities were evaluated.

Main Results:

  • The wet hydrogel demonstrated injectability and structural integrity.
  • The one-plate method allowed systematic tuning of drug release rates by adjusting phosphate content.
  • Dry hydrogels exhibited tunable absorption capacities for water, organic solvents, and oil.
  • SEM and 29Si NMR confirmed porous structures and hybrid siloxane bridges.

Conclusions:

  • This BSA-based composite hydrogel system is versatile, functioning effectively in both wet and dry states.
  • The developed one-plate platform streamlines drug delivery studies and parameter optimization.
  • The tunable absorption properties of the dry hydrogels open avenues for absorbent material development.