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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
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Enzyme-Responsive Peptide-Based AIE Bioprobes.

Juliang Yang1, Jiaming Wei1, Fan Luo2

  • 1Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China.

Topics in Current Chemistry (Cham)
|October 7, 2020
PubMed
Summary
This summary is machine-generated.

Enzyme-responsive peptide-based aggregation-induced emission (AIE) bioprobes offer precise detection of enzyme activity and targeted drug delivery for disease treatment. These bioprobes utilize specific enzyme-triggered aggregation strategies for enhanced biomedical imaging and therapy.

Keywords:
AIE bioprobesCouplingEnzymePeptidePrecipitateSelf-assembly

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Area of Science:

  • Biomedical Engineering
  • Molecular Imaging
  • Biochemistry

Background:

  • Enzymes play crucial roles in biological processes, and their dysregulation is linked to various diseases, making them valuable biomarkers.
  • Aggregation-Induced Emission (AIE) bioprobes offer superior photostability and signal-to-noise ratio for detecting enzyme activity and monitoring drug release.
  • Peptide-based AIE bioprobes are increasingly utilized due to their excellent biocompatibility and specificity.

Purpose of the Study:

  • To review enzyme-responsive peptide-based AIE bioprobes for biomedical applications.
  • To categorize aggregation strategies employed by these bioprobes.
  • To discuss their utility in disease detection and image-guided therapy.

Main Methods:

  • Summarizing enzyme-responsive peptide-based AIE bioprobes based on three aggregation strategies: enzyme-triggered precipitation, enzyme-catalyzed coupling, and enzyme-instructed self-assembly.
  • Presenting representative examples to illustrate detection mechanisms and therapeutic applications.
  • Analyzing current challenges and future directions in the field.

Main Results:

  • Enzymatic hydrolysis of peptides can induce AIE molecule aggregation and facilitate drug release.
  • Three distinct aggregation strategies (precipitation, coupling, self-assembly) enable enzyme activity detection.
  • These bioprobes demonstrate potential for disease diagnosis and image-guided treatment.

Conclusions:

  • Enzyme-responsive peptide-based AIE bioprobes represent a promising platform for sensitive enzyme detection and targeted drug delivery.
  • Further research is needed to address current limitations and fully realize their clinical potential.
  • These advanced bioprobes hold significant promise for the future of precision medicine.