Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cochlea01:13

The Cochlea

49.6K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
49.6K
Auditory Pathway01:15

Auditory Pathway

6.7K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
6.7K
Hearing01:31

Hearing

55.9K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
55.9K
Hair Cells01:22

Hair Cells

43.8K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
43.8K
Anatomy of the Ear01:16

Anatomy of the Ear

10.6K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
10.6K
Auditory Perception01:17

Auditory Perception

844
The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the...
844

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blocking acid-sensing ion channel 1a attenuates bilirubin-induced ototoxicity in cochlear organotypic culture.

Fundamental research·2026
Same author

Clinical doses of gadodiamide have no damaging effects on cochlear tissue in vitro and in vivo.

Neurotoxicology·2025
Same author

Organ of Corti macrophages: a distinct group of cochlear macrophages with potential roles in supporting cell degeneration and survival.

Frontiers in immunology·2025
Same author

Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.

Cerebral cortex (New York, N.Y. : 1991)·2025
Same author

Supporting cell involvement in cochlear damage and repair: Novel insights from a quantitative analysis of cyclodextrin-induced ototoxicity in mice.

Hearing research·2025
Same author

Multifunctional redox modulator prevents blast-induced loss of cochlear and vestibular hair cells and auditory spiral ganglion neurons.

Scientific reports·2024

Related Experiment Video

Updated: Dec 6, 2025

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
09:23

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

Published on: May 24, 2018

9.9K

Can auditory brain stem response accurately reflect the cochlear function?

Dalian Ding1,2,3, Jianhui Zhang2, Wenjuan Li4

  • 1Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York.

Journal of Neurophysiology
|October 7, 2020
PubMed
Summary
This summary is machine-generated.

Compound action potential (CAP) testing offers superior insights into cochlear damage compared to auditory brain stem response (ABR). CAP accurately reflects sensory cell health and detects cross-hearing, unlike ABR.

Keywords:
auditory brain stem responseauditory functioncochlear compound action potentialcochlear lesions

More Related Videos

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

12.2K
Evaluation of Auditory Brainstem Response in Chicken Hatchlings
09:32

Evaluation of Auditory Brainstem Response in Chicken Hatchlings

Published on: April 1, 2022

3.3K

Related Experiment Videos

Last Updated: Dec 6, 2025

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
09:23

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

Published on: May 24, 2018

9.9K
Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

12.2K
Evaluation of Auditory Brainstem Response in Chicken Hatchlings
09:32

Evaluation of Auditory Brainstem Response in Chicken Hatchlings

Published on: April 1, 2022

3.3K

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Otoacoustic Emissions

Background:

  • Auditory brain stem response (ABR) and compound action potential (CAP) are electrophysiological measures used to assess hearing sensitivity in animal models.
  • ABR is more frequently employed for evaluating cochlear lesions due to its testing simplicity.
  • The dynamic changes in auditory function and asymmetric hearing loss following cochlear damage require precise assessment methods.

Purpose of the Study:

  • To compare the efficacy of ABR and CAP in monitoring auditory function changes after cochlear damage.
  • To evaluate the ability of ABR and CAP to detect asymmetric hearing loss caused by unilateral cochlear damage.
  • To elucidate the differences in sensitivity and specificity between ABR and CAP in assessing cochlear pathology.

Main Methods:

  • Two cochlear damage models were utilized: noise-induced trauma in chinchillas and surgical destruction in guinea pigs.
  • ABR and CAP were recorded in both models to assess hearing thresholds.
  • Cochlear hair cell counts were performed post-evoked potential testing to correlate with physiological findings.

Main Results:

  • In noise-induced damage, ABR showed threshold recovery, while CAP indicated irreversible sensory cell damage without recovery.
  • Unilateral cochlear damage led to cross-hearing in both ABR and CAP recordings.
  • ABR failed to detect cross-hearing, whereas CAP exhibited a waveform alteration, signaling its occurrence.

Conclusions:

  • CAP testing provides a more accurate reflection of cochlear sensory cell status than ABR.
  • CAP is more effective than ABR in identifying cross-hearing in cases of asymmetric hearing loss.
  • CAP offers a superior method for assessing the progression of cochlear pathogenesis and functional recovery.