Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epistaxis

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...

Chronic Pharyngitis

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

Nose and Nasal Cavity

Nose and Nasal Cavity

The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...

Anatomy of Respiratory System I: Upper Respiratory Tract

Anatomy of Respiratory System I: Upper Respiratory Tract

The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pleural malignant mesothelioma versus pleuropulmonary synovial sarcoma: a clinicopathological study of 22 cases with molecular analysis and survival data.

Pathology·2018

Same author

Selected Case From the Arkadi M. Rywlin International Pathology Slide Club: Peritoneal Lipofuscinosis and Deciduosis in Pregnancy.

Advances in anatomic pathology·2018

Same author

Selected Case From the Arkadi M. Rywlin International Pathology Slide: Massive Localized Lymphedema in Morbid Obesity Complicated by a Nonspecific Subcutaneous Abscess.

Advances in anatomic pathology·2015

Same author

Selected Case From the Arkadi M. Rywlin International Pathology Slide Club: Polypoid Endometriosis in the Pouch of Douglas in a Perimenopausal Woman.

Advances in anatomic pathology·2015

Same author

Selected case from the Arkadi M. Rywlin International Pathology Slide Club: aggressive angiomyxoma, left labial region in a postmenopausal woman.

Advances in anatomic pathology·2013

Same author

Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.

Advances in anatomic pathology·2012

Same journal

Pathobiology and Interactions of the MiTF Signaling Pathways.

Advances in anatomic pathology·2026

Same journal

Diagnosis and Reporting of Intraductal Carcinoma of the Prostate: A Guide for Practising Pathologists With Excerpts From the Genitourinary Pathology Society and the International Society of Urological Pathology Joint Expert Consultation.

Advances in anatomic pathology·2026

Same journal

An Update on Soft Tissue Tumors of the Paratesticular Region.

Advances in anatomic pathology·2026

Same journal

Recognizing Familial Thyroid Neoplasia: The Pathologist's Role in Diagnosis and Management.

Advances in anatomic pathology·2026

Same journal

Hereditary and Familial Tumor Syndromes: When to Think of Them? The Emerging Role of Pathologists as Sentinels of Genetic Cancer Predisposition.

Advances in anatomic pathology·2026

Same journal

From Familial Clustering to a Dedicated Classification: The Historical Recognition of Hereditary Tumor Syndromes in the WHO Classification of Tumors.

Advances in anatomic pathology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 6, 2025

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Published on: November 1, 2024

Giant Rhinophyma.

Yan Wang¹, Philip W Allen²

¹Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Advances in Anatomic Pathology

|October 7, 2020

Summary

This summary is machine-generated.

Preoperative core biopsies for giant rhinophyma are unnecessary and can be misleading. Definitive surgical excision provides accurate diagnosis, avoiding potential misdiagnosis from non-representative biopsies.

More Related Videos

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

Author Spotlight: Advancing Awake Nasotracheal Intubation with Flexible Video Rhino-Laryngoscopes

Author Spotlight: Advancing Awake Nasotracheal Intubation with Flexible Video Rhino-Laryngoscopes

Published on: August 2, 2024

Related Experiment Videos

Last Updated: Dec 6, 2025

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Published on: November 1, 2024

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

Author Spotlight: Advancing Awake Nasotracheal Intubation with Flexible Video Rhino-Laryngoscopes

Author Spotlight: Advancing Awake Nasotracheal Intubation with Flexible Video Rhino-Laryngoscopes

Published on: August 2, 2024

Area of Science:

Dermatology
Pathology

Background:

Giant rhinophyma is a benign sebaceous hyperplasia of the nose.
Standard practice often includes biopsy before surgical excision of skin lesions.

Observation:

A patient with clinically obvious giant rhinophyma underwent a core biopsy.
The biopsy was non-representative, leading to an incorrect diagnosis of perifollicular fibroma.
Subsequent surgical excision allowed for a definitive diagnosis.

Findings:

Histopathological examination revealed characteristic features of giant rhinophyma, including dilated follicular pores, keratin-plugged follicles, prominent sebaceous glands, and fibrous tissue.
The findings confirmed that preoperative core biopsies are not essential for diagnosing giant rhinophyma.

Implications:

Preoperative core biopsies for giant rhinophyma may be unnecessary and can lead to diagnostic errors.
Surgical excision is sufficient for accurate diagnosis and treatment of giant rhinophyma.