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Language of a Long-Term Relationship: Bacterial Inositols and the Intestinal Epithelium
Antonella Fazio1, Philip Rosenstiel1
1Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.
Abstract:
The exact principles guiding host-microbe homeostasis in the intestinal tract remain obscure. In a recent issue of Nature, Wu et al. (2020) describe that bacterial-derived inositols are an important principle that shapes regenerative properties of the colonic epithelium. The metabolites activate HDAC3, which represents an important part of the epigenetic machinery.
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