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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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The hispanic landscape of triple negative breast cancer

Alejandra Zevallos1, Leny Bravo1, Denisse Bretel2

  • 1Escuela de Medicina Humana, Universidad Privada San Juan Bautista, Lima, Peru.

Critical Reviews in Oncology/Hematology
|October 7, 2020
PubMed

Insights

Triple-negative breast cancer (TNBC) disproportionately affects Hispanic and Afrodescendant women. This review explores TNBC

Area of Science:

  • Oncology
  • Epidemiology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive cancer lacking standard targeted therapies.
  • TNBC exhibits a higher prevalence in Hispanic and Afrodescendant women compared to Caucasian women.
  • Understanding TNBC's unique epidemiological and molecular characteristics is crucial for improving outcomes.

Purpose of the Study:

  • To review the epidemiological, clinicopathological, and molecular features of TNBC.
  • To focus on the specific characteristics of TNBC within the Hispanic population.
  • To investigate the correlation between TNBC prevalence and the human development index.

Main Methods:

  • Literature review of epidemiological studies on TNBC.
  • Analysis of clinicopathological data in Hispanic patients.
  • Examination of molecular profiles of TNBC.
  • Exploration of socioeconomic factors, including human development index, in relation to TNBC prevalence.

Main Results:

  • TNBC is characterized by aggressive biology and limited targeted treatment options.
  • Significant disparities in TNBC prevalence exist across different ethnic groups, notably higher in Hispanic and Afrodescendant women.
  • Specific epidemiological, clinicopathological, and molecular features of TNBC in Hispanic populations are detailed.
  • A potential correlation between TNBC prevalence and the human development index is suggested.

Conclusions:

  • TNBC presents unique challenges due to its aggressive nature and ethnic disparities.
  • Further research into TNBC in Hispanic populations is warranted to address specific health inequities.
  • Understanding the interplay between socioeconomic factors and TNBC biology may inform targeted prevention and treatment strategies.
Keywords:
EpidemiologyEthnicityHuman development indexTriple-negative breast cancer

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