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Updated: Dec 6, 2025

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis
Sandip Patel1, Karl-Johan Malmberg2
1Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
None:
The mammalian two-pore channels TPC1 and TPC2 are patho-physiologically relevant endo-lysosomal cation channels regulated by the Ca2+ mobilising messenger NAADP and the phosphoinositide PI(3,5)P2. Recent work by Arlt et al shows that genetic or chemical inhibition of TPC1 in mice promotes anaphylaxis in vivo through a mechanism involving enhanced endoplasmic reticulum Ca2+ release and secretion in mast cells.
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