Related Experiment Video
Updated: Dec 6, 2025

08:18
Engineered Vascularized Muscle Flap
Published on: January 11, 2016
8.5K
Combined Tissue Transfer for Extensive Lower Limb Complex Defects: Flow-through Flaps, Chimera, and "Orochi" Flaps
1International Center for Lymphedema (ICL), Hiroshima University Hospital, Hiroshima City, Japan.
Journal of Reconstructive Microsurgery
|October 7, 2020
Summary
Combined tissue transfers using minimally invasive perforator flaps offer versatile solutions for complex lower limb defects, including osteomyelitis and nerve palsy. These techniques enable reliable revascularization and custom composite flaps for improved patient outcomes.
Area of Science:
- Reconstructive Surgery
- Microsurgery
- Tissue Engineering
Background:
- Complex lower limb defects, such as those caused by osteomyelitis, present significant reconstructive challenges.
- Traditional methods may involve extensive donor-site morbidity and limited reconstructive options.
Purpose of the Study:
- To demonstrate the application of combined tissue transfers using perforator flaps for severe complex leg defects.
- To highlight the utility of chimeric or "Orochi" type combined transfers.
Main Methods:
- Utilizing minimally invasive perforator flaps combined with well-vascularized bone flaps.
- Employing reliable revascularization techniques like bypass, flow-through, or vein grafts.
- Integrating vascularized nerve flaps for cases with nerve palsy.
Main Results:
- Combined tissue transfers allow for the creation of custom-made composite flaps tailored to specific defect requirements.
- These methods facilitate effective revascularization and reconstruction of complex lower extremity injuries.
- The approach minimizes donor-site deformity.
Conclusions:
- Combined tissue transfers with perforator flaps are effective for reconstructing severe complex leg defects.
- Future advancements suggest increased availability of less invasive donor site techniques for combined tissue transfers.

