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Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade

Sun Tae Hwang1, Min Hee Yang1,2, Alan Prem Kumar3,4

  • 1Department of Science in Korean Medicine, Kyung Hee University, Seoul 02447, Korea.

Biomolecules
|October 8, 2020
PubMed

Insights

Corilagin (CLG) inhibits cancer cell metastasis by modulating the epithelial-to-mesenchymal transition (EMT). This natural compound reduces tumor cell invasion and migration, offering potential as an anti-cancer therapeutic agent.

Area of Science:

  • Pharmacology
  • Cancer Biology
  • Molecular Medicine

Background:

  • Corilagin (CLG), a plant-derived compound, possesses known anti-cancer, anti-inflammatory, and hepatoprotective properties.
  • The epithelial-to-mesenchymal transition (EMT) is a critical process in cancer progression, facilitating tumor cell dissemination and metastasis.
  • No previous studies have investigated the impact of Corilagin on EMT.

Purpose of the Study:

  • To investigate the effect of Corilagin (CLG) on the epithelial-to-mesenchymal transition (EMT) process in tumor cells.
  • To elucidate the underlying mechanisms by which CLG influences EMT and metastasis.

Main Methods:

  • Treatment of tumor cells with Corilagin (CLG).
  • Analysis of epithelial and mesenchymal marker expression.
  • Assessment of cellular invasion and migration assays.
  • Investigation of the Wnt/β-catenin signaling pathway.

Main Results:

  • Corilagin (CLG) reduced the expression of epithelial markers and increased Occludin and E-cadherin levels.
  • CLG treatment significantly abrogated cellular invasion and migration in colon and prostate carcinoma cells.
  • CLG attenuated the Wnt/β-catenin signaling cascade in TGFβ-stimulated cells.

Conclusions:

  • Corilagin (CLG) demonstrates potential as an inhibitor of EMT and metastasis in neoplastic cells.
  • CLG may serve as a valuable therapeutic agent for managing cancer progression and metastasis.
Keywords:
Wnt/β-catenincorilaginepithelial-to-mesenchymal transitioninvasionmigration

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