Related Experiment Videos
[Clinical study and effect of nitroxoline on fecal flora in children]
Insights
Nitroxoline effectively treated urinary tract infections in children, with no adverse effects on their fecal flora. This study highlights nitroxoline
Area of Science:
- Pediatric infectious diseases
- Pharmacology and microbiology
Context:
- Urinary tract infections (UTIs) are common in children.
- Nitroxoline is an antibiotic used for UTIs.
Purpose:
- To evaluate the clinical and bacteriological efficacy of nitroxoline in pediatric patients with UTIs.
- To assess the impact of nitroxoline treatment on the fecal flora of children.
Summary:
- A study involved 12 children treated with nitroxoline for UTIs and 21 children for fecal flora analysis.
- High urinary nitroxoline concentrations (>16 mg/l) correlated with successful outcomes.
- The treatment showed 8 successes, 1 failure, and 3 non-compliance-related failures, with no observed changes in fecal flora.
Impact:
- Nitroxoline demonstrates significant clinical and bacteriological efficacy in treating pediatric UTIs.
- The antibiotic appears safe for fecal microbiota, suggesting a favorable safety profile.
Abstract:
Twelve children (mean age: 4) are treated in practice office with nitroxoline (200 mg/kg/24 h) during 10 days for urinary tract infection. A study on the effect of nitroxoline against the fecal flora is undertaken in a group of 21 children who receive nitroxoline during 4 days or a long period. Bacteriological and clinical efficacy is checked when urinary concentrations of nitroxoline are greater than 16 mg/l. The results show 8 clinical and bacteriological success one true failure and 3 failure due to a non-compliance to the treatment. No qualitative and quantitative modification of the fecal flora is observed after treatment with nitroxoline.