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Updated: Dec 6, 2025
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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
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SP prevents T2DM complications by immunomodulation.
Sang-Min Baek1,2, Kiyoung Kim3, Suna Kim4
1College of Medicine/East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea.
Scientific Reports
|October 8, 2020
Summary
Substance-P (SP) treatment improved metabolic and inflammatory markers in Type 2 Diabetes Mellitus (T2DM) rats. SP also protected against diabetic retinopathy, suggesting therapeutic potential for T2DM complications.
Area of Science:
- Endocrinology
- Immunology
- Ophthalmology
Background:
- Type 2 Diabetes Mellitus (T2DM) involves systemic inflammation and insulin resistance, leading to complications like retinopathy.
- Obesity exacerbates T2DM by promoting inflammation and impairing stem cell function.
Purpose of the Study:
- To investigate the therapeutic effects of substance-P (SP) on T2DM progression and its associated complications.
- To evaluate SP's impact on glucose metabolism, lipid metabolism, systemic inflammation, and retinopathy in a T2DM rat model.
Main Methods:
- Otsuka Long-Evans Tokushima Fatty (OLETF) rats, exhibiting T2DM symptoms, were intravenously injected with SP.
- Effects were assessed at 2 and 4 weeks post-injection, focusing on metabolic parameters, inflammation, stem cell function, and retinal histology.
Main Results:
- SP treatment inhibited weight gain, reduced levels of free fatty acids, cholesterol, and triglycerides, and suppressed inflammation.
- SP rejuvenated bone marrow stem cells, resolved hyperglycemia, and improved insulin resistance.
- Histological analysis showed SP treatment restored retinal structure, mitigating diabetic retinopathy.
Conclusions:
- Systemic SP administration ameliorates obesity, inflammation, and metabolic dysfunction in T2DM.
- SP demonstrates significant potential in inhibiting T2DM progression and reversing diabetic retinopathy.
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