ASSESSMENT OF SERUM ALARIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
F Kilinc1, F Demircan2, N Gozel3
1Firat University, School of Medicine, Dept. of Endocrinology, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|October 8, 2020
Summary
Serum alarin levels are significantly lower in individuals with type 2 diabetes mellitus (T2DM) compared to healthy controls. This study suggests alarin may have prognostic value in T2DM management.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Biochemistry
Background:
- Type 2 Diabetes Mellitus (T2DM) is a global health concern.
- Alarin is a peptide hormone with potential roles in metabolic regulation.
- Understanding biomarkers for T2DM is crucial for effective management.
Purpose of the Study:
- To investigate the relationship between plasma alarin levels and T2DM.
- To compare alarin levels in T2DM patients with and without complications against healthy individuals.
Main Methods:
- A cross-sectional study included 154 participants.
- Participants were categorized into four groups: T2DM without complications, T2DM with microvascular complications, T2DM with macrovascular complications, and a healthy control group.
- Serum alarin levels were measured and compared across groups.
Main Results:
- Serum alarin levels were significantly lower in all T2DM patient groups compared to the healthy control group (p<0.05).
- No significant differences in alarin levels were observed among the T2DM subgroups (with or without complications).
- Control group alarin levels (15.6±2.6 ng/mL) were substantially higher than T2DM groups (ranging from 2.8±0.4 to 3.6±0.4 ng/mL).
Conclusions:
- Serum alarin levels are markedly reduced in patients with T2DM.
- Alarin may serve as a potential biomarker in T2DM.
- Further research is warranted to explore the clinical utility of alarin in T2DM management.
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