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THE ROLE OF NT PRO-BNP IN THE EVALUATION OF DIABETIC PATIENTS WITH HEART FAILURE

F I Fringu1, A V Sitar-Taut2, B Caloian3

  • 1University of Medicine and Pharmacy, Clinical Rehabilitation Hospital, Cardiology Department, Cluj-Napoca, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)
|October 8, 2020
PubMed

Insights

NT-pro-BNP levels are crucial for evaluating diabetic patients with heart failure (HF). These levels correlate with key health indicators and aid in management, especially in patients with diabetes mellitus (DM).

Area of Science:

  • Cardiology
  • Endocrinology
  • Biomarkers

Background:

  • The co-occurrence of heart failure (HF) and diabetes mellitus (DM) presents a significant clinical challenge due to high prevalence.
  • Effective management strategies for these patients require accurate assessment tools.

Purpose of the Study:

  • To investigate the diagnostic and prognostic role of NT-pro-BNP levels in patients with both diabetes and heart failure.
  • To identify specific clinical parameters that correlate with NT-pro-BNP levels in this patient cohort.

Main Methods:

  • A retrospective cohort study involving 174 patients diagnosed with HF.
  • Patients were assessed for the presence of DM, with 47.7% having concomitant diabetes.
  • NT-pro-BNP levels were measured, with a threshold of 126 pg/mL indicating a high probability of HF.

Main Results:

  • In diabetic HF patients, NT-pro-BNP levels showed significant correlations with hemoglobin, hematocrit, total cholesterol, triglycerides, ejection fraction, end-diastolic volume, and end-systolic volume.
  • Independent predictors of elevated NT-pro-BNP included ejection fraction, hemoglobin, and triglycerides.
  • These findings highlight specific biomarkers associated with NT-pro-BNP in diabetic HF.

Conclusions:

  • NT-pro-BNP is a pivotal biomarker for evaluating the status of diabetic patients with heart failure.
  • Utilizing NT-pro-BNP facilitates appropriate management and follow-up strategies for this complex patient group.
Abstract

Keywords:
NT-pro-BNPdiabetes mellitusheart failure

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