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A Retrospective Analysis of the Coagulation Dysfunction in COVID-19 Patients

Xu Chen1, Qinghua Wang2, Min Xu3

  • 1Department of 1/Laboratory Medicine, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|October 8, 2020
PubMed

Insights

D-dimer levels can help identify severe COVID-19 cases. This study found D-dimer, prothrombin time, and thrombin time were higher in severe patients, with D-dimer showing the best predictive value.

Area of Science:

  • * Internal Medicine
  • * Hematology
  • * Infectious Diseases

Background:

  • * COVID-19 is associated with coagulation dysfunction, impacting disease severity.
  • * Identifying reliable biomarkers is crucial for managing COVID-19 patients.
  • * Distinguishing between mild and severe cases aids in timely and appropriate medical intervention.

Purpose of the Study:

  • * To investigate coagulation abnormalities in COVID-19 patients.
  • * To identify potential biomarkers for differentiating severe from mild COVID-19 cases.
  • * To evaluate the predictive value of coagulation parameters in COVID-19 severity.

Main Methods:

  • * Retrospective analysis of 88 COVID-19 patients.
  • * Comparison of coagulation function tests between severe and mild COVID-19 patient groups.
  • * Statistical analysis including Area Under the Curve (AUC) for biomarker evaluation.

Main Results:

  • * Prothrombin time (PT), thrombin time (TT), and D-dimer were significantly elevated in severe COVID-19 patients (P < 0.05).
  • * D-dimer demonstrated the highest predictive value with an AUC of 0.91.
  • * PT and TT showed AUCs of 0.80 and 0.61, respectively.

Conclusions:

  • * D-dimer is a valuable biomarker for predicting severe COVID-19 progression.
  • * Elevated D-dimer levels (84.4% sensitivity, 88.8% specificity) effectively distinguish severe from mild cases.
  • * Coagulation parameters, particularly D-dimer, play a significant role in COVID-19 severity assessment.

Keywords:
biomarkersblood coagulation factorscoagulation

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