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Updated: Dec 6, 2025

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Efficient one-pot, three-component procedure to prepare new α-aminophosphonate and phosphonic acid acyclic
Laila Baddi1, Driss Ouzebla1, Az-Eddine El Mansouri1
1Unité de Chimie Biomoléculaire et Médicinale, Laboratoire de Chimie Biomoléculaire, Faculte des Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco.
Abstract:
An efficient one-pot three-component Kabachnik-Fields reaction of aldehydes (acyclic nucleosides), amines (or amino acid), and triethyl phosphite proceeded for the synthesis of aminophosphonates using natural phosphate coated with iodine (I2@NP) as a catalyst. The novel α-aminophosphonate and phosphonic acid acyclic nucleosides were tested for their anti-HCV and anti-HIV activities. The molecular docking showed that the non-activity of these compounds could be due to the absence of hydrophobic pharmacophores.
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