Related Experiment Video

Updated: Dec 6, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.9K

Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary

Daria F Bechsgaard1, Jens D Hove1,2, Marie M Michelsen3

  • 1Department of Cardiology, Hvidovre University Hospital, University of Copenhagen, Copenhagen, Denmark.

Clinical Physiology and Functional Imaging
|October 8, 2020
PubMed

Insights

Women with angina and no obstructive coronary artery disease have reduced myocardial perfusion reserve (MPR). Coronary microvascular dysfunction (CMD) significantly lowers MPR, indicating transthoracic Doppler echocardiography and CT myocardial perfusion are not interchangeable for CMD detection.

Area of Science:

  • Cardiology
  • Diagnostic Imaging
  • Vascular Biology

Background:

  • Coronary microvascular dysfunction (CMD) affects many women with angina and non-obstructive coronary artery disease (CAD), impacting prognosis.
  • Transthoracic Doppler echocardiography (TTDE) and CT myocardial perfusion (CTP) assess coronary microvascular function via coronary flow velocity reserve (CFVR) and myocardial perfusion reserve (MPR), respectively.
  • The correlation between CFVR and MPR in this population is unknown.

Purpose of the Study:

  • To assess the correlation between CFVR measured by TTDE and MPR measured by CTP.
  • To investigate if women with angina and CMD have reduced MPR compared to asymptomatic women.

Main Methods:

  • Static CTP and TTDE were performed on 99 women with stable angina and no obstructive CAD, and 33 asymptomatic women with no obstructive CAD.
  • Adenosine and dipyridamole were used for vasodilation during CTP and TTDE, respectively.
  • Coronary microvascular dysfunction (CMD) was defined as CFVR < 2.

Main Results:

  • A weak but significant correlation was found between rate-pressure product corrected MPR and CFVR (r=0.23; p=0.007).
  • Asymptomatic women with normal CFVR had the highest MPR (158%).
  • Symptomatic women with CMD exhibited the lowest MPR (140%), even after adjusting for cardiovascular risk factors and hemodynamics.

Conclusions:

  • Women with angina, CMD, and no obstructive CAD demonstrate significantly diminished MPR compared to asymptomatic women.
  • The weak correlation between CFVR and MPR suggests that CTP and TTDE are not interchangeable for detecting CMD.
  • These findings highlight the utility of MPR in identifying CMD in women with angina and non-obstructive CAD.
Abstract

Keywords:
anginacoronary flow velocity reservecoronary microvascular diseasemyocardial perfusion reservewomen

More Related Videos

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice05:07

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice

Published on: August 25, 2023

1.7K
Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

8.3K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
118
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
165
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
514
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
626