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A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl

Gisela Schnapp1, Yvette Hoevels1, Remko A Bakker2

  • 1Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstr. 65, 88397, Biberach, Germany.

Chemmedchem
|October 8, 2020
PubMed

Keywords:
DPP-4FAPkineticslinagliptinpH dependence

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