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Related Experiment Videos

Granulocyte elastase and white cell counts in septic pigs.

M Siebeck, H Hoffmann, R Geiger

    Progress in Clinical and Biological Research
    |January 1, 1987
    PubMed
    Summary

    In early septicemia (blood poisoning), white blood cells called polymorphonuclear granulocytes collect and release enzymes into the lungs and bloodstream.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Pathophysiology

    Background:

    • Sepsis involves a systemic inflammatory response.
    • The role of specific immune cells and enzymes in early sepsis is not fully understood.

    Purpose of the Study:

    • To investigate the behavior of polymorphonuclear granulocytes and lysosomal elastase during early septicemia.

    Main Methods:

    • Analysis of immune cell sequestration.
    • Measurement of lysosomal elastase levels in respiratory tract and circulation.

    Main Results:

    • Data indicate sequestration of polymorphonuclear granulocytes in early sepsis.
    • Evidence suggests local release of lysosomal elastase into the respiratory tract and circulation.

    Conclusions:

    • Polymorphonuclear granulocyte sequestration and lysosomal elastase release are characteristic of early septicemia.
    • Findings contribute to understanding the early inflammatory mechanisms in sepsis.

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