[A 19-year-old woman with fever and high blood pressure]

Area of Science:

• Infectious Diseases
• Cardiology
• Endocrinology

Background:

• A 19-year-old female presented with febrile illness.
• Initial diagnosis revealed a bronchopulmonary infection caused by methicillin-sensitive Staphylococcus aureus (MSSA).

Observation:

• The MSSA infection complicated into infective endocarditis with mitral valve involvement and two splenic abscesses.
• Physical examination suggested Cushing's syndrome, later confirmed by investigations, indicating general immune deficiency.

Findings:

• Successful resolution of infection-related complications including splenic abscesses was achieved through targeted antibiotic therapy and laparoscopic surgery.
• Transsphenoidal resection of a pituitary adenoma led to normalization of previously difficult-to-manage hypertension.

Implications:

• This case highlights the successful management of complex infectious endocarditis and splenic abscesses.
• It underscores the link between Cushing's syndrome, immune deficiency, and hypertension, with surgical intervention proving effective for pituitary adenoma-related complications.