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Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Medicolegal Implications of Biphasic Anaphylaxis
Ugo Da Broi1, Carlo Moreschi1, Giulia Marega1
1From the Department of Medicine, Forensic Medicine, University of Udine, Udine, Italy.
Abstract:
Biphasic anaphylaxis is an uncommon IgE-mediated condition whose pathophysiological mechanisms, risk factors, and predictive signs are not properly understood. Fortunately, the lethality of biphasic anaphylaxis, although probably underestimated, is low. Preventive clinical measures for biphasic anaphylaxis are neither standardized nor commonly applied. Furthermore, there are no laboratory protocols or anaphylactic markers to help identify the onset of biphasic anaphylaxis in clinical settings. The aim of this review is to highlight the medicolegal difficulties facing coroners and forensic pathologists in terms of the diagnosis and assessment of harm for victims and survivors of biphasic anaphylaxis.
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