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Association Between Pediatric Delirium and Quality of Life After Discharge
Gabrielle Silver1, Hannah Doyle, Emily Hegel
1All authors: Weill Cornell Medical College, New York, NY.
Insights
Pediatric delirium significantly impacts young children's quality of life long after hospital discharge. Children experiencing delirium had lower scores in all quality of life domains compared to those who did not.
Area of Science:
- Pediatric critical care medicine
- Child psychology
- Quality of life research
Background:
- Delirium is common in critically ill children, especially those under five.
- Understanding the long-term effects of pediatric delirium is crucial for comprehensive care.
Purpose of the Study:
- To assess the residual impact of pediatric delirium on quality of life.
- To evaluate quality of life at one and three months post-hospital discharge.
Main Methods:
- Prospective observational cohort study in a pediatric intensive care unit (PICU).
- Screened children under five for delirium using the Cornell Assessment for Pediatric Delirium.
- Measured quality of life with the Infant-Toddler Quality of Life questionnaire at baseline, one, and three months post-discharge.
Main Results:
- 27% of enrolled children developed delirium during their PICU stay.
- Children with delirium scored lower in all quality of life domains compared to those without.
- Delirious patients had an 11-point lower general health score, even after controlling for illness severity.
Conclusions:
- Pediatric delirium is independently associated with reduced quality of life in young children post-discharge.
- This pilot study highlights the persistent negative effects of delirium on child well-being.
Objective:
Delirium occurs frequently in critically ill children, with highest rates reported in children under 5 years old. The objective of this study was to measure the residual effect of delirium on quality of life at 1 and 3 months after hospital discharge.
Design:
Prospective observational cohort study.
Setting:
Urban academic PICU.
Patients:
Children younger than five years of age at time of admission to the PICU.
Interventions:
All children were screened for delirium (using the Cornell Assessment for Pediatric Delirium) throughout their stay in the PICU. Quality of life was measured using the Infant-Toddler Quality of Life questionnaire at three time points: baseline, 1 month, and 3 months after hospital discharge. Infant-Toddler Quality of Life scores were compared between children who did and did not develop delirium.
Measurements And Main Results:
Two hundred seven children were enrolled. One hundred twenty-two completed the 1-month follow-up, and 117 completed the 3-month follow-up. Fifty-six children (27%) developed delirium during their PICU stay. At follow-up, Infant-Toddler Quality of Life scores for the PICU cohort overall were consistently lower than age-related norms. When analyzed by delirium status, children who had experienced delirium scored lower in every quality of life domain when compared with children who did not experience delirium. Even after controlling for severity of illness, delirious patients demonstrated an average 11-point lower general health score than nondelirious patients (p = 0.029).
Conclusion:
This pilot study shows an independent association between delirium and decreased quality of life after hospital discharge in young children.
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