Related Experiment Video
Updated: Dec 6, 2025
13:10
Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
Published on: September 25, 2016
10.2K
99mTc-Mebrofenin SPECT/CT in Hepatic Infarction
Govind S Mattay1, Cathal O'Leary2, Jacob G Dubroff2
1From the Perelman School of Medicine at the University of Pennsylvania.
Clinical Nuclear Medicine
|October 8, 2020
Summary
Hereditary hypercoagulability increased hepatic infarction risk post-liver transplant. Technetium-99m mebrofenin SPECT/CT identified infarction, confirmed by MRI, leading to successful anticoagulation therapy.
Area of Science:
- Nuclear medicine
- Radiology
- Hepatology
Background:
- Hereditary hypercoagulability presents a significant risk factor for thrombotic events, including hepatic infarction.
- Liver transplantation, particularly living-donor procedures, requires vigilant monitoring for post-operative complications.
Observation:
- A 68-year-old male liver transplant recipient presented with elevated aminotransferases, prompting investigation for hepatic complications.
- Technetium-99m mebrofenin single-photon emission computed tomography/computed tomography (SPECT/CT) was employed to assess liver function and perfusion.
Findings:
- SPECT/CT revealed a distinct wedge-shaped area of decreased radiotracer uptake in the anterior liver segment, indicative of hepatic infarction.
- Magnetic resonance imaging (MRI) with contrast enhancement confirmed the diagnosis of hepatic infarction.
Implications:
- Early diagnosis of hepatic infarction using nuclear medicine imaging is crucial for prompt management.
- Initiation of oral anticoagulation therapy effectively resolved the infarction and normalized liver enzymes, highlighting the importance of addressing hypercoagulability post-transplant.
