Sampling methods and feature selection for mortality prediction with neural networks

Along with digitization, automatic data-driven decision support systems become increasingly popular. Mortality prediction is a vital part of that decision process. With more data available, sophisticated machine learning models like (Artificial) Neural Networks (NNs) can be applied and promise favorable performance. We evaluate the reproducibility of a published mortality prediction approach using NNs along with the possibility to generalize it to a bigger and more generic dataset. We describe an extensive preprocessing pipeline, as well as the evaluation of different sampling techniques and NN architectures. Through training on a loss function that optimizes both, precision and recall, in combination with a good set of hyperparameters and a set of new features, we use a NN to predict in-hospital mortality with accuracy, sensitivity, and area under the receiver operating characteristic score of greater than 0.8.