Related Experiment Video
Updated: Dec 6, 2025
Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
Published on: November 17, 2020
"Borderline" idiopathic CD4+ T-cell lymphocytopenia presenting with atypical progressive multifocal
Clemente Dato1, Andrea Elefante2, Cinzia Coppola1
1Department of Advanced Medical and Surgical Sciences, Second Division of Neurology - University of Campania "Luigi Vanvitelli", via Pansini 5, 80131 Naples, Italy.
Abstract:
Idiopathic CD4+ lymphocytopenia (ICL) is a rare disorder characterized by low counts of CD4+ cells (<300/mm3) in absence of other known causes of immunosuppression. A few cases of progressive multifocal leukoencephalopathy (PML) were reported in association with ICL with variable outcome. We describe the case of a 40 year-old man diagnosed with PML, which showed a monophasic course. Causes of primary and secondary immunodeficiency were ruled out, only a "borderline" ICL was found. This case highlights that a severe immunodepression could not be an absolute prerequisite in developing PML and also points the attention on current definition of ICL.
