Associations between air pollution and outpatient visits for arrhythmia in Hangzhou, China

Arrhythmia is a common cardiovascular event that is associated with increased cardiovascular health risks. Previous studies that have explored the association between air pollution and arrhythmia have obtained inconsistent results, and the association between the two in China is unclear.

We collected daily data on air pollutants and meteorological factors from 1st January 2014 to 31st December 2016, along with daily outpatient visits for arrhythmia in Hangzhou, China. We used a quasi-Poisson regression along with a distributed lag nonlinear model to study the association between air pollution and arrhythmia morbidity.

The results of the single-pollutant model showed that each increase of 10 μg/m³ of Fine particulate matter (PM_2.5), Coarse particulate matter (PM₁₀), Sulphur dioxide (SO₂), Nitrogen dioxide (NO₂), and Ozone (O₃) resulted in increases of 0.6% (- 0.9, 2.2%), 0.7% (- 0.4, 1.7%), 11.9% (4.5, 19.9%), 6.7% (3.6, 9.9%), and - 0.9% (- 2.9, 1.2%), respectively, in outpatient visits for arrhythmia; each increase of 1 mg/m³ increase of carbon monoxide (CO) resulted in increase of 11.3% (- 5.9, 31.6%) in arrhythmia. The short-term effects of air pollution on arrhythmia lasted 3 days, and the most harmful effects were observed on the same day that the pollution occurred. Results of the subgroup analyses showed that SO₂ and NO₂ affected both men and women, but differences between the sexes were not statistically significant. The effect of SO₂ on the middle-aged population was statistically significant. The effect of NO₂ was significant in both the young and middle-aged population, and no significant difference was found between them. Significant effects of air pollution on arrhythmia were only detected in the cold season. The results of the two-pollutants model and the single-pollutant model were similar.

SO₂ and NO₂ may induce arrhythmia, and the harmful effects are primarily observed in the cold season. There is no evidence of PM_2.5, PM₁₀, CO and O₃ increasing arrhythmia risk. Special attention should be given to sensitive populations during the high-risk period.