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Swedish multicenter study on prepyloric and gastric ulcer.
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1987
Summary
Sucralfate and cimetidine effectively treat gastric and prepyloric ulcers, showing comparable healing rates and symptom relief. Both medications are well-tolerated with minimal side effects for short-term ulcer management.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Gastric and prepyloric ulcers (GU/PPU) require effective short-term treatment options.
- Sucralfate and cimetidine are established therapeutic agents for ulcer management.
Purpose of the Study:
- To compare the efficacy of sucralfate versus cimetidine in treating gastric and prepyloric ulcers.
- To evaluate ulcer healing rates and symptomatic relief in a randomized, double-blind, multicenter trial.
Main Methods:
- Double-blind, randomized, multicenter study comparing sucralfate and cimetidine.
- Endoscopic evaluation of ulcer healing at 4-week intervals up to 8 weeks (PPU) and 12 weeks (GU).
- 142 PPU patients and 134 GU patients completed the study.
Main Results:
- Overall 8-week healing rates: 83% (sucralfate) vs. 90% (cimetidine) for PPU (NS).
- Cumulative 12-week healing rates: 98% (sucralfate) vs. 94% (cimetidine) for GU (NS).
- No significant difference in symptomatic relief; side effects were non-specific and minor.
Conclusions:
- Sucralfate and cimetidine are both highly effective healing agents for short-term treatment of PPU and GU.
- Both drugs provide rapid symptomatic relief with a favorable safety profile.
- No significant differences were observed in healing efficacy or symptom resolution between the two treatments.