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Whole-Genome Assemblies for Two Yersinia pestis Strains Isolated in Mongolia

Muzi Jin1, B Byambajav2, Hongyuan Zheng3

  • 1Huhhot Customs District, Huhhot, China.

Microbiology Resource Announcements
|October 9, 2020
PubMed

Insights

Researchers sequenced the genomes of two Yersinia pestis bv. Antiqua strains from Mongolia. These bacteria were found circulating in marmot populations, providing insights into plague epidemiology.

Area of Science:

  • Microbiology
  • Genomics
  • Epidemiology

Background:

  • Yersinia pestis is the causative agent of plague.
  • Understanding the genetic diversity of Yersinia pestis is crucial for tracking disease outbreaks.
  • Marmots are known reservoirs for Yersinia pestis, particularly in Central Asia.

Purpose of the Study:

  • To perform draft genome sequencing of two Yersinia pestis bv. Antiqua strains.
  • To analyze the genetic characteristics of Yersinia pestis strains circulating in Mongolian marmot populations.
  • To contribute to the understanding of plague's evolutionary history and geographic spread.

Main Methods:

  • Whole-genome sequencing of Yersinia pestis isolates.
  • Bioinformatic analysis of the obtained draft genomes.
  • Phylogenetic analysis to determine the placement within the Yersinia pestis 3.ANT phylogroup.

Main Results:

  • The draft genome sequences of two Yersinia pestis bv. Antiqua strains were successfully generated.
  • Both strains belong to the 3.ANT phylogroup, indicating a specific evolutionary lineage.
  • The isolates were confirmed to be from marmot populations in Mongolia.

Conclusions:

  • The genomic data provide valuable insights into the genetic makeup of Yersinia pestis in Mongolian marmots.
  • This study enhances our understanding of plague epidemiology and the diversity of Yersinia pestis strains.
  • The findings support ongoing surveillance efforts for Yersinia pestis in wildlife reservoirs.

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