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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Published on: July 28, 2013

Diffusion imaging in Huntington's disease: comprehensive review.

Carlos Estevez-Fraga¹, Rachael Scahill¹, Geraint Rees^2,3

¹Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.

Journal of Neurology, Neurosurgery, and Psychiatry

|October 9, 2020

Summary

Huntington's disease (HD) progression can be tracked using diffusion MRI, revealing white matter degeneration in premanifest stages. This technology aids in understanding neurodegeneration and evaluating treatment effects in clinical trials.

Keywords:

Huntington's MRI image analysis movement disorders

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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

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Published on: March 11, 2020

Area of Science:

Neuroimaging
Neuroscience
Genetics

Background:

Huntington's disease (HD) is a monogenic disorder with 100% penetrance.
Early, premanifest stages of HD exhibit detectable brain changes.
Investigating microstructural alterations offers insights into brain organization and neurodegeneration.

Purpose of the Study:

To investigate microstructural brain changes in early and premanifest Huntington's disease using diffusion MRI.
To understand the pattern and progression of white matter degeneration in HD.
To assess the utility of diffusion MRI in clinical trials for HD.

Main Methods:

Diffusion MRI techniques including voxelwise analysis, region of interest, and tractography.
Analysis of white matter degeneration patterns.
Application of advanced techniques like multitissue compartment models and connectomics.

Main Results:

Diffusion MRI reveals a centrifugal pattern of white matter degeneration in HD, starting in deep brain areas.
Degeneration affects the corpus callosum, long white matter tracts, and densely connected networks like the sensorimotor network early in premanifest stages.
Diffusion analyses show potential as a biomarker for tracking disease progression and treatment effects.

Conclusions:

Diffusion MRI is a valuable tool for detecting and tracking microstructural brain changes in Huntington's disease, even in premanifest stages.
Understanding the pattern of degeneration aids in comprehending HD's neurodegenerative process.
Diffusion MRI analyses should be considered for inclusion in clinical trials to enhance understanding of treatment efficacy.