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Related Experiment Video

Updated: Dec 6, 2025

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

Bioengineered human blood vessels.

Laura E Niklason^1,2, Jeffrey H Lawson^3,4

¹Departments of Anesthesiology and Biomedical Engineering, Yale University, New Haven, CT, USA. laura.niklason@yale.edu lawson@humacyte.com.

Science (New York, N.Y.)

|October 9, 2020

Summary

This summary is machine-generated.

Engineered human arteries, utilizing advances in connective tissue engineering, physiology, and biomanufacturing, are poised to revolutionize vascular disease treatment.

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Last Updated: Dec 6, 2025

Bioengineering Human Microvascular Networks in Immunodeficient Mice

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Published on: July 11, 2011

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Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

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Published on: March 27, 2017

Area of Science:

Biomedical Engineering
Vascular Biology
Regenerative Medicine

Background:

Vascular anastomosis, pioneered by Alexis Carrel, has been crucial for treating vascular injuries and diseases.
Arterial grafts have evolved from early artificial materials to modern polymer fabrics.
Understanding of arterial physiology and cell biology has advanced significantly.

Purpose of the Study:

To highlight the progress and potential of engineered human arteries in surgical therapy.
To discuss the interdisciplinary advancements enabling the development of artificial arteries.
To position engineered arteries as a future mainstay for treating vascular disease.

Main Methods:

Leveraging recent advances in connective tissue engineering.
Integrating knowledge from physiology and cell biology.
Utilizing progress in biomanufacturing techniques.

Main Results:

Engineered human arteries are nearing clinical application.
Interdisciplinary progress has paved the way for artificial artery development.
These engineered vessels promise to be a significant therapeutic option.

Conclusions:

Engineered human arteries represent a major advancement in vascular surgery.
The convergence of multiple scientific fields is driving this innovation.
Artificial arteries are expected to become a standard treatment for vascular conditions.