Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

188
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
188
Expected Value01:15

Expected Value

7.0K
The expected value is known as the "long-term" average or mean. This means that over the long term of experimenting over and over, you would expect this average. The expected average is represented by the symbol μ. It is calculated as follows:
7.0K
Gaussian Elimination: Problem Solving01:30

Gaussian Elimination: Problem Solving

90
Systems of linear equations in several variables are pivotal in modeling complex scenarios involving multiple unknowns and constraints. Such systems are widely used in various fields to represent relationships where several conditions must be simultaneously satisfied. Each variable in the system corresponds to an unknown quantity, while each equation imposes a linear constraint, leading to a structured approach for analyzing and solving real-world problems.A system of three equations with three...
90
Quadratic Models01:23

Quadratic Models

94
Quadratic models are mathematical representations used to describe relationships in which the rate of change changes at a constant rate. These models appear in a wide variety of natural and engineered systems, especially those involving motion, forces, and optimization. One common application is analyzing the vertical motion of objects influenced by gravity, such as a ball thrown into the air.In such scenarios, the object's height changes over time in a curved pattern, rising to a maximum point...
94
Probability Distributions01:32

Probability Distributions

11.3K
 The probability of a random variable x  is the likelihood of its occurrence. A probability distribution represents the probabilities of a random variable using a formula, graph, or table. There are two types of probability distribution– discrete probability distribution and continuous probability distribution.
A discrete probability distribution is a probability distribution of discrete random variables. It can be categorized into binomial probability distribution and Poisson...
11.3K
Central Limit Theorem01:14

Central Limit Theorem

19.0K
The central limit theorem, abbreviated as clt, is one of the most powerful and useful ideas in all of statistics. The central limit theorem for sample means says that if you repeatedly draw samples of a given size and calculate their means, and create a histogram of those means, then the resulting histogram will tend to have an approximate normal bell shape. In other words, as sample sizes increase, the distribution of means follows the normal distribution more closely.
The sample size, n, that...
19.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic estimates of global causes of neonatal and under 5 mortality in 2000-24: secondary data analysis using bayesian multinomial logistic regression.

BMJ (Clinical research ed.)·2026
Same author

Toward a Principled Workflow for Prevalence Mapping Using Household Survey Data.

Journal of survey statistics and methodology·2026
Same author

TEMPORAL MODELS FOR ESTIMATION AND SHORT-TERM FORECASTING OF NEONATAL MORTALITY RATES IN SUB-SAHARAN AFRICA.

The annals of applied statistics·2026
Same author

Applying machine learning to identify unrecognized COVID-19 deaths recorded as other causes of death in the United States.

Science advances·2026
Same author

Bayesian Tensor Decomposition for Clustering Latent Symptom Profiles for Verbal Autopsy Data.

Statistics in medicine·2026
Same author

What's the Weight? Estimating Controlled Outcome Differences in Complex Surveys for Health Disparities Research.

Statistics in medicine·2025
Same journal

Probabilistic Joint and Individual Variation Explained (ProJIVE) for Data Integration.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

fastkqr: A Fast Algorithm for Kernel Quantile Regression.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Empirical Bayes Covariance Decomposition, and a Solution to the Multiple Tuning Problem in Sparse PCA.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Joint Registration and Conformal Prediction for Partially Observed Functional Data.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Efficient Decision Trees for Tensor Regressions.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Distributed Nonparametric Regression with Heterogeneity Through Prediction-Based Aggregation.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
See all related articles

Related Experiment Video

Updated: Dec 6, 2025

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.8K

An Expectation Conditional Maximization approach for Gaussian graphical models.

Zehang Richard Li1, Tyler H McCormick2

  • 1Department of Biostatistics, Yale School of Public Health.

Journal of Computational and Graphical Statistics : a Joint Publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America
|October 9, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a deterministic Expectation Conditional Maximization (ECM) algorithm as a computationally feasible alternative for estimating Bayesian graphical models in high-dimensional settings, improving posterior exploration and information integration.

Keywords:
copula graphical modelsparse precision matrixspike-and-slab prior

More Related Videos

A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

14.1K
Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.6K

Related Experiment Videos

Last Updated: Dec 6, 2025

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.8K
A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

14.1K
Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.6K

Area of Science:

  • Computational statistics
  • Machine learning
  • Statistical modeling

Background:

  • Bayesian graphical models are valuable for understanding complex variable dependencies, especially with prior information.
  • High-dimensional data presents computational challenges for traditional Bayesian stochastic search methods.
  • Existing methods struggle with the vast search space of possible graphs in high-dimensional scenarios.

Purpose of the Study:

  • To propose a computationally efficient and deterministic alternative to existing Bayesian graphical model estimation methods.
  • To extend the Expectation-Maximization (EM) algorithm for Bayesian variable selection to graphical model estimation.
  • To enable the estimation of Gaussian and Gaussian copula graphical models in high-dimensional settings.

Main Methods:

  • Developed a novel Expectation Conditional Maximization (ECM) algorithm.
  • Extended the EM algorithm framework for Bayesian graphical model estimation.
  • Applied the ECM algorithm to Gaussian and Gaussian copula graphical models.

Main Results:

  • The proposed ECM algorithm provides a computationally feasible deterministic alternative.
  • Demonstrated fast posterior exploration capabilities of the ECM approach.
  • Showcased the ability of the ECM algorithm to incorporate multiple sources of prior information.

Conclusions:

  • The ECM algorithm offers an efficient method for estimating Bayesian graphical models, particularly in high-dimensional data.
  • This approach overcomes the computational limitations of traditional stochastic search methods.
  • The ECM algorithm facilitates the integration of external prior information into graphical model estimation.